Research, Clinical Trials & Publications
Advancing ophthalmic care through evidence-based research and clinical innovation.
60+ Peer-Reviewed Publications
Principal Investigator – Clinical Trials
DM (Research), Cranfield University
Dr. Bhaskar Gupta holds a distinguished academic profile alongside a demanding clinical practice, demonstrating a steadfast commitment to scientific inquiry and clinical education.
Higher Research Degree
The foundation of Dr. Bhaskar Gupta’s academic career is the attainment of a Doctorate in Medicine (Research) (DM) from Cranfield University, UK. This extensive, focused research investigated crucial ophthalmic topics, including the study of ethnic variation in diabetic retinopathy.
Dr. Bhaskar Gupta’s core research interests are directly aligned with clinical specialism, focusing on:
- Diabetic Retinopathy
- Wet Age-Related Macular Degeneration
- Retinal Detachment
- Post-Operative Ocular Infection
Driving Future Eye Care
The pursuit of optimal patient outcomes demands more than just surgical skill; it requires a direct engagement with innovation. As a Principal Investigator (PI) in numerous national and commercial clinical trials, Dr. Bhaskar Gupta is at the forefront of ophthalmic research. This leadership role ensures that patients at University Hospital Southampton have early access to novel drugs and devices, often years before they become widely available. The role of the Principal Investigator (PI) is one of ultimate accountability, demanding adherence to strict ethical guidelines, protocol fidelity, and the protection of patient safety and welfare. Dr. Bhaskar Gupta's involvement in clinical trials reflects a commitment to the highest standard of ethical research and the rapid translation of scientific discovery into practical patient benefit.
Clinical Trials & Principal Investigator Roles
Driving Future Eye Care
Active Clinical Trial Portfolio
Dr. Bhaskar Gupta leads the site-specific conduct of several critical clinical trials, focusing on high-impact areas within vitreo-retinal surgery and medical retina
Trial/Study name :
| Focus Area | Role & Significance |
|---|---|
| Post-operative Endophthalmitis (Ocular Infection) | Principal Investigator (PI): This study aims to define the optimal surgical and medical strategy for managing this sight-threatening complication following intraocular surgery. |
Trial/Study name :
TIGER STUDY
| Focus Area | Role & Significance |
|---|---|
| Wet Age-Related Macular Degeneration (AMD) | Principal Investigator (PI): Investigating the potential of a novel subretinal therapy combined with vitrectomy, advancing beyond standard injection-based treatments. |
Trial/Study name :
DIAGRID TRIAL
| Focus Area | Role & Significance |
|---|---|
| Wet Age-Related Macular Degeneration (AMD) | Principal Investigator (PI): A commercial trial investigating the use of a novel port delivery system (PDS) for long-acting drug delivery in macular degeneration. |
Trial/Study name :
Gene Therapy Trials
| Focus Area | Role & Significance |
|---|---|
| Genetic Retinal Diseases & Age-Related Macular Degeneration (AMD) | Key Investigator: Active involvement in pioneering gene therapy trials for wet and dry age-related macular degeneration and inherited retinal disorders, representing the forefront of translational research. |
Why Clinical Research Matters
Access to Innovation
Evidence Based Practice
Global Contribution
Publication Record & Teaching
With more than 60 publications in peer-reviewed journals, Dr. Bhaskar Gupta consistently contributes high-impact data to the global ophthalmology community. This academic standing is further recognised by Dr. Bhaskar Gupta’s role as an invited reviewer for various academic journals.
Dr. Bhaskar Gupta is also heavily involved in training, serving as a trainer for the Basic Phaco Emulsification Course and an Examiner for the Royal College of Ophthalmologists.
Dr. Bhaskar Gupta views research as a vital extension of clinical practice, dedicated to translating scientific advances into tangible benefits for patients.With over 60 peer-reviewed publications to his credit, his work is featured in prestigious, high-impact journals such as the British Journal of Ophthalmology and Survey of Ophthalmology, journals renowned for publishing clinically relevant research across all areas of ophthalmology and vision science.
His published research focuses on improving surgical outcomes, defining disease prevalence, and advancing therapeutic strategies in vitreo-retinal disorders, diabetic eye disease, and ocular infections. Dr. Bhaskar’s contributions underscore a commitment to evidence-based medicine and reflect his active role as an educator and peer reviewer for various journals.
Full List of Selected Peer-Reviewed Publications
Vitreo-Retinal Surgery, Techniques, and Outcomes
- Trends and emerging patterns of practice in vitreoretinal surgery. | B Gupta, J E Neffendorf, T H Williamson, R Wong | Acta Ophthalmologica | Nov 2018 (Epub May 2016)
- Predicting visual success in macular hole surgery. | B Gupta, D A H Laidlaw, T H Williamson, et al. | British Journal of Ophthalmology | 2009
- Surgical and visual outcome following 20-gauge vitrectomy in proliferative diabetic retinopathy. | B Gupta, T H Williamson, R Wong, S Sivaprasad | Eye (Referenced in Vitreoretinal Surgery, 3rd ed.) | 2012
- Ethnic variation in vitreoretinal surgery: differences in clinical presentation and outcome. | B Gupta, J E Neffendorf, T H Williamson, R Wong | European Journal of Ophthalmology (Referenced in Vitreoretinal Surgery, 3rd ed.) | 2017
Diabetic Retinopathy (DR) and Clinical Trials
- Ethnic variations in the prevalence of diabetic retinopathy in people with diabetes attending screening in the United Kingdom (DRIVE UK). | S Sivaprasad, B Gupta, M C Gulliford, et al. | PloS one | 2012
- Prevalence of diabetic retinopathy in various ethnic groups: a worldwide perspective. | S Sivaprasad, B Gupta, R Crosby-Nwaobi, et al. | Survey of Ophthalmology | 2012
- Visual and anatomical outcomes following vitrectomy for complications of diabetic retinopathy: the DRIVE UK study. | S Sivaprasad, B Gupta, J A Ratnayaka, et al. | Eye (London) | 2012
- Intravitreal gas injection for the treatment of diabetic macular edema. | D McHugh, B Gupta, M Saeed | Clinical Ophthalmology | Oct 2011
Macular Degeneration (AMD) and Ocular Pathology
- Treatment of submacular hemorrhage with tissue plasminogen activator and pneumatic displacement in age-related macular degeneration. | I Careba, H Almuhtaseb, B Gupta, et al. | (Not specified) | Dec 2019
- Functional and structural characteristics in patients with diabetic macular oedema after switching from ranibizumab to aflibercept treatment. Three year results in real world settings. | A Sepetis, H Clarke, B Gupta, et al. | (Not specified) | Dec 2022
- Epiretinal membranes in patients with uveitis: an update on the current state of management. | A Sepetis, H Clarke, B Gupta, et al. | (Not specified) | (Not specified)
- Sickle cell disease and the eye: old and new concepts. | M Elagouz, S Jyothi, B Gupta, S Sivaprasad | Survey of Ophthalmology | 2010
Ocular Infection and Inflammation
- Endogenous fungal endophthalmitis: international, multicentre, retrospective analysis of clinical outcomes following surgical and medical management, and screening. | D Kalogeropoulos, A Lotery, B Gupta, et al. | (Not specified) | Oct 2025
- Bilateral endophthalmitis following bilateral same‐day anti‐VEGF injections. | A Sepetis, B Clarke, B Gupta | (Not specified) | June 2020
- Should Routine Eye Examinations Be Included in Treatment Bundles for Patients with Candidemia? | H Russell Day, J B Bond, B Gupta, et al. | (Not specified) | April 2021
- The Collaborative Ocular Tuberculosis Study (COTS)-1 Report 3: Polymerase Chain Reaction in the Diagnosis and Management of Tubercular Uveitis: Global Trends. | R Agrawal, B Gupta, C E Pavesio, et al. | (Not specified) | (Not specified)
- Anti-tubercular therapy for intraocular tuberculosis: a systematic review and meta-analysis. | A R Kee, J J Gonzalez-Lopez, A Al-Hity, B Gupta, et al. | Survey of Ophthalmology | 2016
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